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KMID : 0380519970010010040
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Korean Journal of Veterinary Pathology
1997 Volume.1 No. 1 p.40 ~ p.45
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Phototoxicity studies of LB20304a
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Kim Bae-Hwan
Lee Sang-Koo
Yoon Byong-Ill
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Abstract
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The phototoxic potentials of LB20304a a new quinolone compound being developed by LG Chemical Ltd, and reference compounds (Ciprofloxacin; CPFX, Enoxacin; ENX and Lomefloxacin; LFLX) were compared in a murine model. in addition photostability of these compunds was studied after irradiation with long-wave UV light(UVA, 0, 0.3 1 or 3 Joule/㎠) When hairless mice(9 to 11 weeks old 19-26g) were orally administered with different dose levels of test compunds and exposed to UVA(40J/㎠) inflammatory reactions were observed in a dose dependent manner. Among the compounds tested, LB20304a demonstrated the least phototoxic effects and showed no inflammatroy lesions at a dose level of 100mg.kg (Low dose). ENX and LFLX demonstrated much greater phototoxic reactions while CPFX showed similar or slightly greater phototoxic reactions compared to LB20304a. Similar to the in-vivo results the solutions of LB20304a and CPFX irradiated with UVA demonstrated reduced spectral changes compared to those of ENX and LFLX. In conclusion these data suggest that phototoxic potencies of the quinolones tested were; LFLX > ENX > CPFX ≥ LB20304a. No phototoxic dose of LB20304a in mice was 100 mg/kg.
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KEYWORD
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Hairless mice, in-vivo, in-vitro photostability, LB20304a, Phototoxicity, Quinolone, UVA
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